منابع مشابه
The Use of Synthetic Carriers in Malaria Vaccine Design.
Malaria vaccine research has been ongoing since the 1980s with limited success. However, recent improvements in our understanding of the immune responses required to combat each stage of infection will allow for intelligent design of both antigens and their associated delivery vaccine vehicles/vectors. Synthetic carriers (also known as vectors) are usually particulate and have multiple properti...
متن کاملAn Epidemiological Model of Malaria Accounting for Asymptomatic Carriers
Abstract. Asymptomatic individuals in the context of malarial disease refers to subjects who carry a parasite load but do not show clinical symptoms. A correct understanding of the influence of asymptomatic individuals on transmission dynamics will provide a comprehensive description of the complex interplay between the definitive host (femaleAnopheles mosquito), intermediate host (human) and a...
متن کاملOn designing stable magnetic vectors as carriers for malaria DNA vaccine.
Superparamagnetic iron oxide nanoparticles (SPIONs) can be used as therapeutic and diagnostic agents due to their unique magnetic characteristics, provided that they are stable in physiological conditions. Here, the assembly of different magnetic vector configurations comprising SPIONs, polyethylenimine (PEI), and hyaluronic acid (HA), acting as carriers for malaria DNA vaccine encoding Plasmod...
متن کاملDifferences in Gene Transcriptomic Pattern of Plasmodium falciparum in Children with Cerebral Malaria and Asymptomatic Carriers
The mechanisms underlying the heterogeneity of clinical malaria remain largely unknown. We hypothesized that differential gene expression contributes to phenotypic variation of parasites which results in a specific interaction with the host, leading to different clinical features of malaria. In this study, we analyzed the transcriptomes of isolates obtained from asymptomatic carriers and patien...
متن کاملPharmaceutical Particulate Carriers: Lipid - Based Carriers
Drug delivery research areas is continuously broaden and modified as a results of the realization of many factors (such as poor drug solubility and/or absorption, rapid metabolism, high fluctuation in the drug plasma level and variability) adversely affect in-vivo results, in conventional drug delivery system. Lipids are one of the basic building blocks of biological membranes. Nanoscale-based ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1995
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.951031081